Polysorbate 20 / 60 / 80
The question

Is Polysorbate 20 / 60 / 80 safe in serum?

CautionSerum

PEG-derived emulsifiers that stabilize oil-water mixtures. Can be contaminated with 1,4-dioxane and ethylene oxide; may also disrupt gut microbiome when consumed.

What the research flags

  • Potential 1,4-dioxane and ethylene oxide contamination (manufacturing byproducts)
  • Polysorbate 80 linked to gut microbiome disruption and low-grade inflammation in animal studies [inference]
  • Enhances skin penetration
  • PEG-derived — petroleum origin

Regulatory
Ethoxylation process can introduce 1,4-dioxane (IARC Group 2B) as impurity

Other serum ingredients on file

Sources & references

  1. [1]
    DatabaseIngredient database — 705253-POLYSORBATE_80
  2. [2]
    Peer-reviewedPubMed / NCBI — pubmed.ncbi.nlm.nih.gov · ref 25555183
  3. [3]
    RegulatoryUS federal agency — 14-dioxane-cosmetics

Research disclaimer: Ratings reflect peer-reviewed research and regulatory assessments available at the time of publication, not the dose or formulation of any specific serum product. This is not medical advice.