The Lab
Specimen No. 0190
AvoidDerivedfood trans fats and harmful processed fats

Interesterified Fats

Master DB rating: Avoid. Listed for: Modern margarine, commercial shortenings, processed baked goods

medium confidence
Researched July 7, 2026

Concerns

  • In a mouse feeding study, interesterified palm oil impaired insulin signaling and increased insulin secretion versus unmodified palm oil, indicating insulin resistance (Dos Santos et al. 2023)
  • Human postprandial trials are mixed — most find no adverse difference vs. non-interesterified fat, but one crossover trial found an 85% increase in postprandial triglycerides with chemically interesterified fat in obese (not lean) subjects (Robinson et al. 2008)

Regulatory flags

  • IARC Class: NL
  • EDC Status: None
  • Regulatory: US: no specific labeling; often marketed as "natural"
  • Evidence Grade: B

Commonly found in

Modern margarine, commercial shortenings, processed baked goods

Research disclaimer: This rating is based on available peer-reviewed research and regulatory assessments at the time of publication. It is not medical advice. Consult a qualified professional for personal health or skin concerns.

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