The Lab
Specimen No. 0188
AvoidSyntheticfood synthetic preservatives

Calcium Propionate

E282

Master DB rating: Avoid. Listed for: Commercial bread, rolls, baked goods

medium confidence
Researched July 7, 2026

Concerns

  • A double-blind, placebo-controlled crossover trial found children's behavior (irritability, restlessness, sleep disturbance) worsened significantly more often on calcium propionate challenge than on placebo (Dengate & Ruben 2002)
  • Systemic propionic acid administration produces autism-like behavioral and brain ultrastructural changes in rodent models, a plausible but not directly equivalent mechanism [Inference: rodent studies use injected propionic acid, not dietary calcium propionate]

Regulatory flags

  • IARC Class: NL
  • EDC Status: None
  • Regulatory: US: GRAS; EU: permitted; no child-specific safety limits
  • Evidence Grade: B

Commonly found in

Commercial bread, rolls, baked goods

Research disclaimer: This rating is based on available peer-reviewed research and regulatory assessments at the time of publication. It is not medical advice. Consult a qualified professional for personal health or skin concerns.

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LabelCleared verdict badge: Calcium Propionate — Avoid
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