The Lab
Specimen No. 0167
CautionSyntheticsweetenerfood additive

Sucralose (Splenda)

sucralose · e955 · splenda

A chlorinated artificial sweetener approximately 600× sweeter than sugar. FDA and EFSA-approved with an ADI of 15 mg/kg body weight. The WHO issued a cautionary advisory in 2023 suggesting long-term consumption may have health implications not yet fully characterized. Short-term human studies show no significant effects on blood glucose or gut bacteria.

medium confidence
Researched April 18, 2026

Concerns

  • WHO 2023 advisory raises questions about long-term health implications
  • Some studies suggest possible gut microbiome effects at high doses [Inference]
  • Contains chlorine atoms — though not equivalent to chlorinated solvents
  • Long-term safety data still accumulating

Regulatory flags

  • WHO (2023): non-sugar sweeteners not recommended for long-term use

Commonly found in

Diet sodasSugar-free candyLow-calorie foodsProtein barsArtificially sweetened yogurt

Research disclaimer: This rating is based on available peer-reviewed research and regulatory assessments at the time of publication. It is not medical advice. Consult a qualified professional for personal health or skin concerns.

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