The Lab
Specimen No. 0210
CautionDerivedsweetenerfood additive

Sorbitol

CAS 50-70-4 · E420 · D-glucitol · glucitol

A sugar alcohol used in sugar-free gum, diabetic foods and toothpaste. Not systemically toxic, but it is incompletely absorbed, so higher intakes reliably cause gas, bloating and osmotic diarrhea — it is a classic FODMAP trigger.

high confidence
Researched July 7, 2026

Concerns

  • Sorbitol is incompletely absorbed in the small intestine and its absorption is dose- and concentration-dependent; malabsorbed sorbitol is fermented by colonic bacteria, so excess intake commonly causes flatulence, abdominal discomfort and osmotic diarrhea (Montalto et al. review of sorbitol malabsorption)
  • As a FODMAP polyol, sorbitol can provoke or worsen symptoms in people with irritable bowel syndrome; reviews note that symptom severity after a sugar/polyol challenge is greater in IBS patients than in healthy controls (Fernandez-Banares, Nutrients 2022 review of carbohydrate maldigestion)

Regulatory flags

  • IARC Class: NL
  • EDC Status: None
  • Regulatory: US: GRAS, "excess consumption may have a laxative effect" labeling (21 CFR 184.1835); EU: authorized as E420
  • Evidence Grade: A

Commonly found in

Sugar-free gumSugar-free candyDiabetic foodsToothpasteCough syrups

Research disclaimer: This rating is based on available peer-reviewed research and regulatory assessments at the time of publication. It is not medical advice. Consult a qualified professional for personal health or skin concerns.

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