The Lab
Specimen No. 0202
CautionSyntheticsunscreen filter

Dioxybenzone

CAS 131-53-3 · Benzophenone-8 · BP-8 · Dioxybenzone

A benzophenone chemical UV filter that can cause allergic and photoallergic contact dermatitis and for which US regulators have requested more safety data.

medium confidence
Researched July 7, 2026

Concerns

  • Benzophenone organic UV filters have caused both allergic contact dermatitis and photoallergic contact dermatitis (Ekstein 2023, PMID 36279254)
  • A case report documented an anaphylactoid reaction to benzophenone sunscreens, including benzophenone-8 (dioxybenzone), with recurrence during patch testing (Tawfik 2019, PMID 31006868)

Regulatory flags

  • IARC Class: NL
  • EDC Status: Not established
  • Regulatory: US FDA: not classified GRASE, additional safety data requested (2019/2021 proposals); EU: permitted UV filter (Annex VI)
  • Evidence Grade: B

Commonly found in

SunscreenLip balm with SPFAnti-aging cream with SPF

Research disclaimer: This rating is based on available peer-reviewed research and regulatory assessments at the time of publication. It is not medical advice. Consult a qualified professional for personal health or skin concerns.

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