Specimen No. 0072
AvoidSyntheticfood additivesweetener
Artificial Sweeteners (Aspartame, Sucralose, Acesulfame-K)
aspartame · e951 · sucralose
Non-caloric synthetic sweeteners. IARC classified aspartame as a possible carcinogen (Group 2B) in 2023. Sucralose and Ace-K alter gut microbiome and may disrupt glucose metabolism.
medium confidence
Researched April 18, 2026Specimen 0072Artificial Sweeteners (Aspartame, Sucralose, Acesulfame-K)
Concerns
- Aspartame: IARC Group 2B possible carcinogen (2023) — based on limited evidence of hepatocellular carcinoma
- Sucralose alters gut microbiome composition in animal studies
- Acesulfame-K: metabolized to acetoacetamide — possible carcinogen at high doses [inference]
- Paradoxical weight gain suggested in some studies — possible insulin response triggering
Regulatory flags
- ⚑WHO (2023): non-sugar sweeteners not recommended for long-term use or weight management
- ⚑Aspartame: IARC Group 2B possible carcinogen (2023)
Commonly found in
Diet sodaSugar-free gumYogurtProtein powder"Zero sugar" products
Sources & references
Last researched: April 18, 2026
Research disclaimer: This rating is based on available peer-reviewed research and regulatory assessments at the time of publication. It is not medical advice. Consult a qualified professional for personal health or skin concerns.
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