The Lab
Specimen No. 0072
AvoidSyntheticfood additivesweetener

Artificial Sweeteners (Aspartame, Sucralose, Acesulfame-K)

aspartame · e951 · sucralose

Non-caloric synthetic sweeteners. IARC classified aspartame as a possible carcinogen (Group 2B) in 2023. Sucralose and Ace-K alter gut microbiome and may disrupt glucose metabolism.

medium confidence
Researched April 18, 2026

Concerns

  • Aspartame: IARC Group 2B possible carcinogen (2023) — based on limited evidence of hepatocellular carcinoma
  • Sucralose alters gut microbiome composition in animal studies
  • Acesulfame-K: metabolized to acetoacetamide — possible carcinogen at high doses [inference]
  • Paradoxical weight gain suggested in some studies — possible insulin response triggering

Regulatory flags

  • WHO (2023): non-sugar sweeteners not recommended for long-term use or weight management
  • Aspartame: IARC Group 2B possible carcinogen (2023)

Commonly found in

Diet sodaSugar-free gumYogurtProtein powder"Zero sugar" products

Research disclaimer: This rating is based on available peer-reviewed research and regulatory assessments at the time of publication. It is not medical advice. Consult a qualified professional for personal health or skin concerns.

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LabelCleared verdict badge: Artificial Sweeteners (Aspartame, Sucralose, Acesulfame-K) — Avoid
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